Document Type and Number:
Japanese Patent JPS4970994
Kind Code:
A
Abstract:
1430778 N1 -Oxides of adenosine derivatives ABBOTT LABORATORIES 11 Sept 1973 [3 Oct 1972] 42748/73 Heading C2C Novel compounds I in which R 1 is hydrogen, C 1-6 alkyl, hydroxy C 1-6 alkyl or halo C 1-6 alkyl and R 2 and R 3 are hydrogen or, when R 1 is hydrogen, they together form an isopropylidene group and their acid addition salts are prepared by forming 21 ,31 - isopropylidene adenosine - N1 - oxide by oxidation of 21 ,31 -isopropylidene adenosine using hydrogen-peroxide, cleaving the ether group to form adenosine-N1 -oxide and reacting the acid with an alcohol R 1 OH in the presence of thionyl chloride. Compounds I in which R 1 is other than hydrogen and R 2 and R 3 are hydrogen are antianginal agents and form with a carrier or diluent a pharmaceutical composition which may be administered orally or parenterally.
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Application Number:
JP11024873A
Publication Date:
July 09, 1974
Filing Date:
October 02, 1973
Export Citation:
International Classes:
C07H19/167; C07H19/16; (IPC1-7): C07D51/54