Document Type and Number:
Japanese Patent JPS50157351
Kind Code:
A
Abstract:
Compositions are provided as well as methods for preparing the compositions which serve as cyclization precursors for the preparation of C-11 alkenyl substituted steroids and nor-steroids. The alkenyl group may be converted after cyclization to a variety of heterosubstituents to provide heterofunctionalized C-11 steroids and nor-steroids. The compounds are provided having an initiator group, which has a chalcoxy atom in juxtaposition to a double bond, an olefinically unsaturated linking group and a terminating group which acts to from a carbocation which reacts with a nucleophile to provide a stable product. The C-11 substituent is found to provide upon cyclization the alpha-configuration, so that the subject compounds provide a direct route to the difficultly accessible alpha-C-11 substituted steroids, or, if desired, the alpha-configuration can be inverted to the beta-configuration.
Application Number:
JP5383475A
Publication Date:
December 19, 1975
Filing Date:
May 02, 1975
Export Citation:
International Classes:
C07J75/00; C07C29/147; C07C45/29; C07C45/41; C07C45/51; C07C45/56; C07C45/59; C07C45/66; C07C47/24; C07C47/277; C07C57/00; C07C57/18; C07C57/52; C07D317/12; C07D317/16; C07D317/20; C07D317/22; C07D339/06; C07J7/00; C07J61/00; (IPC1-7): C07J51/00