Document Type and Number:
Japanese Patent JPS5541207
Kind Code:
B2
Abstract:
A method of inhibiting methotrexate sensitive leukemia L1210 and methotrexate resistant leukemias derived from L1210, such as variants L1210/FR-8, L1210/M-46-R, L1210/C-95, and L1210/M-66-3A in mice. This method produces optimum results as to the resistant leukemias as well as significant activity as to the sensitive leukemia. The compound employed is 5-methyltetrahydrohomofolate utilized as an injectable in a dosage regiment of 12.5-1600 mg/kg/inj/diem. The mechanism of action prefers dosages for at least two to four days, and in mice optimum results are obtained when treatment is commenced on day 1 following leukemia innoculation and is continued to the death of mice.
Application Number:
JP8276773A
Publication Date:
October 22, 1980
Filing Date:
July 24, 1973
Export Citation:
International Classes:
A61K31/495; A61K31/505; A61K31/519; A61P35/02; C07D475/04; (IPC1-7): A61K31/505