Document Type and Number:
Japanese Patent JPS555517
Kind Code:
B2
Abstract:
Trioxopteridine derivatives of the formula , WHEREIN R1 is a normal alkyl group having 0 to 6 hydroxyl groups and R2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R2-A-COOR3, wherein R3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula ¦ R4O-C-OH ¦ wherein R4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.
Application Number:
JP9190772A
Publication Date:
February 07, 1980
Filing Date:
September 13, 1972
Export Citation:
International Classes:
A61K31/505; A61K31/519; A61P25/04; A61P29/00; C07D475/02; (IPC1-7): C07D475/02