Document Type and Number:
Japanese Patent JPS5627515
Kind Code:
B2
Abstract:
By reaction of a bisguanidino compound of formula in which the substituents have the meaning shown in Claim 1, with an isocyanate of formula Z-NCO, the corresponding bis(carbamylguanidine) compounds are obtained. The bisguanidino compound is preferably N,N'-bis(3-guanidinopropyl)piperazine and Z is preferably a 4-chlorophenyl group. The compounds obtained can be used as local antimicrobial agents and more particularly antimicrobial compounds acting against microorganisms which produce dental plaque, having a prolonged intraoral residence time and antimicrobial activity, an acceptable taste, and staining neither the teeth nor the gums.
Application Number:
JP12954476A
Publication Date:
June 25, 1981
Filing Date:
October 29, 1976
Export Citation:
International Classes:
A61K31/395; A61K31/495; A61K31/55; A61P31/04; B65D5/49; C07C279/24; C07C335/38; C07D243/08; C07D245/02; C07D295/12; C07D295/13; C07D295/14