Title:
NOVEL N-AROMATIC GROUP HETEROCYCLIC GROUP SUBSTITUTED PIPERIDINE, PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES, MANUFACTURE AND DRUGS
Document Type and Number:
Japanese Patent JPS5823664
Kind Code:
A
Abstract:
Heterocycles of formula (I) and their acid addition salts are new: In (I) X is N and n is 1 or 2 or X is VH and n is 1. R is H, 1-5C alkylcarbonyl or alkoxycarbonyl, heterocyclylcarbonyl (heterocyclyl is furyl, thienyl, tetrahydrofuryl, pyridyl or 2-methylthio 1,3,4-oxadiazol-5-yl) benzoyl, 3,4,5-trimethoxy cinnamoyl, allyloxycarbonyl, 2-methyl 1-propen-3-yloxycarbonyl, benzyloxycarbonyl or phenoxycarbonyl; R can also be phenylthio provided X is not CH; Ar is 4(7)-benzimidazolyl (opt. 2-substd. by 1-4C alkyl, phenyl or benzyl); 6-purinyl (provided X is not N and H), 4(7)-benzotriazolyl; 7-indolyl; or, when X is N and n is 1, 4-indolyl. (I) are useful as cardiovascular agents, particularly antihypertensives. Typical cpds. have intravenous LD50 in mice 125 mg per kg or more, and can be formulated for daily doses of up to 0.5g.
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Inventors:
JIYANNFURANSEEZU ANCHIYAA
PATORITSUKU GERETSUTO
MISHIERU RANGUROISU
JIYATSUKII TEISUNNBAASEIRESU
PATORITSUKU GERETSUTO
MISHIERU RANGUROISU
JIYATSUKII TEISUNNBAASEIRESU
Application Number:
JP6750982A
Publication Date:
February 12, 1983
Filing Date:
April 23, 1982
Export Citation:
Assignee:
DELALANDE SA
International Classes:
C07D295/18; A61K31/41; A61K31/495; A61K31/496; A61K31/52; A61K31/55; A61P9/12; C07C205/19; C07D209/08; C07D211/62; C07D213/82; C07D235/04; C07D235/06; C07D235/08; C07D249/18; C07D295/205; C07D307/24; C07D307/68; C07D333/36; C07D333/40; C07D401/04; C07D401/12; C07D403/04; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D473/34; C07D487/04; (IPC1-7): A61K31/41; A61K31/495; A61K31/52; A61K31/55; C07D209/08; C07D213/82; C07D235/04; C07D249/18; C07D295/18; C07D307/18; C07D307/68; C07D333/36; C07D401/04; C07D401/12; C07D403/04; C07D405/12; C07D409/12; C07D413/12; C07D473/34
Attorney, Agent or Firm:
Ariga Miyuki