Title:
【発明の名称】GnRH作働薬
Document Type and Number:
Japanese Patent JPS60500057
Kind Code:
A
Abstract:
Peptides for promoting the spawning of fish having the formula: pGlu-His-Trp-Ser-Tyr-R6-Trp-Leu-Pro-R10-NHR or a nontoxic salt thereof, wherein R6 is a D-isomer of an alpha -amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R10 is Gly or des-R10 and R is H or CnY2nCY3, with Y being H or F and n being 0, 1, 2 or 3, provided that when R10 is des-R10, n is not 0. The D-isomer alpha -amino acids may contain known substitutions.
Inventors:
Veil, Wiley Walker The Union
Libert, Jean-Edouard Frederik
Libert, Jean-Edouard Frederik
Application Number:
JP50029784A
Publication Date:
January 17, 1985
Filing Date:
December 05, 1983
Export Citation:
Assignee:
The Salk Institute For Biological Studies
International Classes:
C07K7/06; C07K7/23; C07K14/575; (IPC1-7): C07K7/06
Attorney, Agent or Firm:
Kyozo Yuasa