Japanese Patent JPS6148830

B2

A process for preparing a 5-perfluoroalkyldihydrouracil derivative of the general formulawherein R_f represents a perfluoroalkyl group, each of R¹ and R² represents a hydrogen atom, or an alkyl, cyloalkyl, aryl, aralkyl or heterocyclic group, and Y is an oxygen or sulfur atom, which comprises (a) reacting a compound of the general formulawherein X represents a halogen atom or a hydroxyl group, with a urea derivative of the general formulaprovided that when X is a hydroxyl group and at least one of R¹ and R² is a hydrogen atom, said reaction is carried out in the presence of a consensing agent, or (b) cyclizing a compound of the general formulaand a novel intermediate compound of the above formula (IV).

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OSHIMA IWAO
FUCHIGAMI TAKAMASA
FUJITA MAKOTO

JP15007582A

October 25, 1986

August 31, 1982

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SAGAMI CHEM RES

A61K31/505; A61P35/00; C07C51/10; C07C51/60; C07C275/16; C07C275/24; C07C275/28; C07C335/08; C07C335/12; C07C335/16; C07D239/22; C07D405/14; C07H13/12; C07H19/06; C07H19/067; C07H19/073

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