Document Type and Number:
Japanese Patent JPS6214557
Kind Code:
B2
Abstract:
9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by high local antiinflammatory activity with a reduced systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional replacement of an organic 21-sulphonyloxy group by halogen X2.
Inventors:
YAROSURAFU KARUFUODA
GEORUGU ANNERU
GEORUGU ANNERU
Application Number:
JP11619377A
Publication Date:
April 02, 1987
Filing Date:
September 29, 1977
Export Citation:
Assignee:
CIBA GEIGY
International Classes:
A61K31/57; A61P29/00; C07J5/00; C07J7/00; C07J21/00; C07J31/00; C07J71/00
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