Japanese Patent JPS6242895

B2

Aminoalkylbenzene derivative of the formula: wherein A is oxygen or sulfur; Y is oxo, thioxo, or cyanoimino; a is an integer of 1 to 3; b is an integer of 0 to 3; c is an integer of 1 to 4; R<1> is alkyl; R<2> is hydrogen or alkyl; or R<1> and R<2> taken together represent pyrrolidinyl; R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: wherein R<3> is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy; R<4> is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; or R<3> and R<4> taken together represent alkylidene or aralkylidene; with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents and their acid addition salts being useful as histamine H2 blockers, especially peptic ulcer remedies.

HIRAI KENTARO
ISHIHA TERUYUKI
MATSUTANI SHIGERU
MAKINO ITSUO
FUJISHITA TOSHIO
TSUTSUMIUCHI MASAMI
OOTANI KOICHI

JP8480179A

September 10, 1987

July 03, 1979

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SHIONOGI & CO

C07D295/18; A61K31/16; A61K31/165; A61K31/34; A61K31/341; A61K31/40; A61K31/4015; A61K31/41; A61K31/415; A61K31/42; A61K31/4245; A61K31/435; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/455; A61K31/535; A61K31/5375; A61K31/5377; A61P43/00; C07C67/00; C07C231/00; C07C233/18; C07C233/20; C07C233/22; C07C233/60; C07C233/69; C07C235/20; C07C235/48; C07C235/72; C07C237/08; C07C237/32; C07C237/42; C07C239/00; C07C261/04; C07C301/00; C07C311/18; C07C313/00; C07C323/29; C07C323/39; C07C323/41; C07C325/00; C07C327/40; C07C327/46; C07C327/48; C07C327/50; C07D207/16; C07D207/28; C07D211/60; C07D213/81; C07D213/82; C07D233/90; C07D249/10; C07D257/04; C07D261/18; C07D271/06; C07D295/08; C07D295/096; C07D295/14; C07D295/15; C07D307/68; C07D333/38; C07D335/06; C07D498/04

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