Document Type and Number:
Japanese Patent JPS6254403
Kind Code:
B2
Abstract:
Pharmaceutical compsns. capable of correcting deficiencies in serotonin metabolism compise 5-hydroxytryptophan(5HTP) in association with one or moe purine, pyriidine and/or pyridine deriVs. (I). Also claimed is the pepn. of an inosine-L-5HTP coplex. Specific (I) are inosine, theophylline, theobromine, allopurinol, hypoxanthine, folic acid, nicotinamide, caffeine, and orotic acid. The 5HTP ay be associated with (I) in the form of a complex (pef. 1:1) o a salt. The 5HTP may be in L, D or DL form. Co-admi. of (I) greatl inceases the proportion of 5HTP reaching the bai, so that high cerebral serotonin levels can be maintained using elatiVely low doses of 5HTP.
Inventors:
KUROODO RARUIERU
MARUSERU RUPAN
MARUSERU RUPAN
Application Number:
JP16072882A
Publication Date:
November 14, 1987
Filing Date:
September 14, 1982
Export Citation:
Assignee:
PANMEDEIKA SA
International Classes:
C07D209/20; A61K31/403; A61K31/404; A61K31/405; A61K31/44; A61K31/455; A61K31/505; A61K31/52; A61P43/00; C07D213/67; C07D213/82; C07D473/08; C07D473/10; C07D473/30; C07D475/04; C07D487/04; C07H19/167; C07H19/20