Title:
【発明の名称】1‐置換(S)‐および(R)‐2‐アミノメチルピロリジン類の有効な立体保存的合成およびその中間体
Document Type and Number:
Japanese Patent JPS63503384
Kind Code:
A
Abstract:
Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity wherein R<1> is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is O-3 and Ph is a substituted or unsubstituted phenyl group including l) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline 2) aminolysis 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R<2> is defined as R<1> above. h
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Inventors:
Huedersel, Hans-Jürgen
Hi yogberg, thomas
Remus Biu, Sten Ingvar
Stryllme, Hans Erik Peter
Hi yogberg, thomas
Remus Biu, Sten Ingvar
Stryllme, Hans Erik Peter
Application Number:
JP50338487A
Publication Date:
December 08, 1988
Filing Date:
May 19, 1987
Export Citation:
Assignee:
Astra Lekemedel Actie Borrag
International Classes:
C07B53/00; C07D207/08; C07D207/00; C07D207/09; C07D207/16; (IPC1-7): C07D207/16; C07D207/09
Attorney, Agent or Firm:
Chika Takagi (2 outside)