PURPOSE: To provide novel compounds exhibiting a broad antimicrobial spectrum and, at the same time, a strong anti-bacterial action even against resistant bacteria against various known antibiotics.
CONSTITUTION: The objective compounds are represented by the formula [wherein R1 is H, 1-3C alkyl, 1-4C alkoxycarbonyl, acetyl or (5-methyl-2-oxo-1,3- dioxol-4-yl)-methyl; R2 is H, 1-3C alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl, acetoxymethyl or pivaloyloxymethyl; (n) is 0 or 1; X1 is a halogen or NO2; X2 is H, a halogen, NH2 or methyl; A is H, CH, CF, CCl, CBr, CCF3, C-OCH3, C-CHF2, C-CH3 or C-C≡CH], e.g. 6,8-difluoro-1-(cis-2-fluorocyclopropyl)-1,4- dihydro-7-(5-methyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl)-4-oxo-3- quino-linecarboxylic acid.
TOOMASU SHIENKE
SHIYUTEFUAN BEEMU
RORUFU GUROSAA
KURAUSU DEIITAA BUREMU
RAINAA ENDERUMAN
KAARU GEORUKU METSUTSUGAA