1-(4-フルオロフェニル)-3(R)-[3(S)-ヒドロキシ-3-(4-フルオロフェニル)-プロピル)]-4(S)-(4-ヒドロキシフェニル)-2-アゼチジノンの合成に有用なトランス-2-(アルコキシカルボニルエチル)-ラクタムの分割

Title:

Document Type and Number:

Japanese Patent JP3703719

Kind Code:

B2

Abstract:

A process for the microbiological or enzymatic hydrolytic resolution of racemic trans-2-(alkoxycarbonylethyl) lactams of the formula I: wherein R is C1-C7 alkyl, 2,2,2-trifluoroethyl or methoxyethoxyethyl and R1 is hydrogen or a protecting group is disclosed, whereby an optically enriched compound of the formula Ib or IIa: is obtained.

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Inventors:

Hohmann, Michael Jay.
Morgan, William Brian

Application Number:

JP2000574715A

Publication Date:

October 05, 2005

Filing Date:

October 01, 1999

Export Citation:

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Assignee:

Schering Corporation

International Classes:

C07D205/08; C12P17/10; C12P41/00; C12R1/66; (IPC1-7): C12P41/00

Domestic Patent References:

JP7194392A
JP7327692A
JP9509317A

Other References:

J.Med.Chem.,1998,Vol.41,No.6,p.973-980

Attorney, Agent or Firm:

Hidesaku Yamamoto

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