To obtain a new subject carbapenem derivative that contains a specific 1-methylcarbapaenem derivative, is excellent in antimicrobial activity, stable to dehydropeptidase I with high urinary recovery and is useful as an antimicrobial agent.
This compound is a new 1-methylcarbapanem derivative of formula I [R1 is H, a (substituted) lower alkyl, a lower alkenyl, the formula: C(=NH)R0 (R0 is H, a lower alkyl); R5 is H, a residue of an ester hydrolyzable in vivo; A is a group of formula II ((l) is 0, 1, 2; R7 is the same as stated above; R11 is H, a lower alkyl; R12 is H, a lower alkyl, a lower alkenyl)] or its salt. In addition, this compound has excellent antimicrobial activity and is useful as an antimicrobial agent with high stability to dehydropeptidase I and high urinary recovery. This compound is prepared by reaction of a compound of formula III (R24 is a carboxyl-protecting group) with an alkanesulfonic anhydride, followed by reaction of the product with a compound of formula IV (A' is the same as A; R26 is the same as R1), when necessary, hydrolyzed.
ENDO ROKURO
MIYAUCHI MASAO
WATANABE KATSUHIKO
NAKAYAMA EIJI
YASUDA HIROSHI
OYA SATORU
UTSUI YUKIO
