1-PHENYL-2-PIPERIDINOALKANOL DERIVATIVE

Title:

1-PHENYL-2-PIPERIDINOALKANOL DERIVATIVE

Document Type and Number:

Japanese Patent JPS5989660

Kind Code:

A

Abstract:

Compounds of the formula: (I) wherein R1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R2 is hydroxyl or methoxy in the 4-position and R3 is hydrogen, R1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl, R2 is hydrogen, halogen, alkyl, hydroxyl, or alkoxy, R3 is hydrogen or alkyl, R4 is alkyl (in which case the compounds are (+/-)-erythro) or when R3 represents hydrogen, R4 may also be hydrogen, and R5 is hydrogen, halogen, alkyl, alkoxy, or three methoxy groups in the 3-, 4- and 5-positions and pharmaceutically acceptable acid addition salts thereof, with the exclusion of compounds wherein: (a) one of R1 and R2 is in the 4-position and is hydroxyl, alkoxy or benzyloxy, the other is in the 3-position and is hydrogen, hydroxyl, alkoxy or benzyloxy, and R3 and R5 are hydrogen and wherein: (b) R1 is in the 4-position and is halogen, R4 is methyl and R2, R3 and R5 are hydrogen, are useful as medicaments.

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Inventors:

AREKISANDAA BUITSUKU
JIYONASAN FUROSUTO
BERUNAARU GOODEIRIEERU
JIYAN BARUTAN
REJI DEYUPON
JIYAN RUSOO

Application Number:

JP19059083A

Publication Date:

May 23, 1984

Filing Date:

October 12, 1983

Export Citation:

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Assignee:

SYNTHELABO

International Classes:

A61K31/445; A61K31/451; A61P9/08; A61P25/24; A61P25/26; A61P25/28; C07C45/00; C07C45/45; C07C45/54; C07C45/63; C07C45/71; C07C49/76; C07D211/12; C07C49/80; C07C49/825; C07C49/84; C07C63/70; C07C67/00; C07C69/76; C07D211/14; C07D211/18; C07D211/22; C07D211/26; C07D211/28; C07D211/30; C07D211/32; C07D211/62; C07D213/50; C07D213/78; C07D317/18; C07D317/30; (IPC1-7): A61K31/445; C07C49/76; C07C69/76; C07D211/12; C07D211/14; C07D211/18; C07D211/22; C07D211/28; C07D211/32; C07D211/62; C07D213/50; C07D213/78

Domestic Patent References:

JPS5896067A

1983-06-07

Attorney, Agent or Firm:

Aoyama Aoi

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