NEW MATERIAL:The 1-substituted heterocyclic carboxylic acid amide derivative of formula I (A is alkylene; R1 is H or lower alkyl; NR2R3 is group of formula II or formula III; R4 is phenyl, N-containing heteroaryl, etc.; R5 is H or lower alkyl; R6 and R7 are phenyl; n is 2 or 3; Het is group of formula IV, formula V, etc.; X is N or =CH-; R8 is lower alkyl, etc.; R9, R10 and R11 are H, halogen, trifluoromethyl, etc.; R12 is lower alkyl, (lower) hydroxyalkyl, etc.; R13 is H, lower alkyl, etc.; when X is N, R8 is hydroxy, etc.) and its salt.
USE: It has anti-allergic action based on 5-lipoxygenase inhibiting action and is useful as a drug for the prevention and remedy of bronchial asthma, etc.
PREPARATION: The compound of formula I can be produced by reacting a compound of formula VI with a diamine of formula VII.
NISHIKAWA YOSHINORI
SHINDO NORIHIKO
NAKAMURA HIDEO
ISHII KATSUMI
