Title:
【発明の名称】1-置換-1-アミノメチル-シクロアルカン誘導体(=ガバペンチン類縁体)、その製造および神経学的疾患の治療におけるその使用
Document Type and Number:
Japanese Patent JP2002508362
Kind Code:
A
Abstract:
Novel amines of formulas 1, 1C, 1F, 1G and 1H or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, heterocycle, sulfonic acid, or hydroxamic acid; A' is a bridged ring selected from wherein is the point of attachment; Z1 to Z4 are each independently selected from hydrogen and methyl; o is an integer of from 1 to 4; and p is an integer of from 0 to 2. In formula (1) above R cannot be sulfonic acid when m is 2 and n is 1 are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammatory diseases, and gastrointestinal disorders, especially irritable bowel syndrome.
Inventors:
Justin Stephen Bryans
Thomas Capilis
David Christopher Howell
Claire Octevier Nene
David Juergen Wustrow
Thomas Capilis
David Christopher Howell
Claire Octevier Nene
David Juergen Wustrow
Application Number:
JP2000539002A
Publication Date:
March 19, 2002
Filing Date:
November 10, 1998
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/16; A61K31/18; A61K31/255; A61K31/41; A61K31/4245; A61K31/433; A61K31/662; A61P1/00; A61P25/00; A61P25/04; A61P25/08; A61P25/22; A61P25/24; A61P29/00; C07C233/36; C07C239/14; C07C259/06; C07C309/25; C07D285/08; C07C311/05; C07C311/09; C07C311/33; C07D211/26; C07D257/04; C07D271/06; C07D271/07; C07D285/18; C07D291/04; C07D309/04; C07D335/02; C07D401/06; C07D405/06; C07D409/06; C07D413/06; C07D417/06; C07D419/06; C07F9/38; C07F9/59; C07F9/655; C07F9/6553; A61K31/00; C07D291/00; (IPC1-7): C07D257/04; A61K31/16; A61K31/18; A61K31/255; A61K31/41; A61K31/662; A61P1/00; A61P25/00; A61P25/04; A61P25/08; A61P25/22; A61P25/24; A61P29/00; C07C239/14; C07C311/05; C07D271/06; C07D285/08; C07D291/04; C07F9/38
Domestic Patent References:
| JPS5188940A | 1976-08-04 |
Foreign References:
| WO1997033858A1 | 1997-09-18 | |||
| WO1997033859A1 | 1997-09-18 |
Attorney, Agent or Firm:
Chika Takagi (1 person outside)