Title:
10-DEACETYL BACCATINE III AND 10-DEACETYL 14β-HYDROXY BACCATINE III DERIVATIVE, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL FORMULATION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JP2011046744
Kind Code:
A
Abstract:
To provide new derivatives of 10-deacetyl baccatine III and 10-deacetyl 14β-hydroxy baccatine III having cell toxicity and antitumoral activity.
These derivatives are prepared starting from so-called synthon or other taxane of natural origin, by selective oxidation of hydroxy at site 10 to a keto functional group, and, if necessary, by following esterification of site 13 with variously substituted isoserine chains. The product, if appropriately prepared, can be administered by injection or orally.
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Inventors:
BOMBARDELLI EZIO
DE BELLIS PAOLO
GABETTA BRUNO
DE BELLIS PAOLO
GABETTA BRUNO
Application Number:
JP2010271599A
Publication Date:
March 10, 2011
Filing Date:
December 06, 2010
Export Citation:
Assignee:
INDENA SPA
International Classes:
C07D305/14; A61K31/335; A61K31/337; A61P35/00; C07D263/06; C07D493/10; C07F7/18; C07D263/04
Domestic Patent References:
| JPH069599A | 1994-01-18 |
Foreign References:
| WO1994013655A1 | 1994-06-23 | |||
| WO1994029288A1 | 1994-12-22 | |||
| WO1994027984A1 | 1994-12-08 | |||
| WO1992007842A1 | 1992-05-14 | |||
| WO1994022856A1 | 1994-10-13 | |||
| US5319112A | 1994-06-07 | |||
| US5367086A | 1994-11-22 | |||
| EP0629701A1 | 1994-12-21 | |||
| EP0604910A1 | 1994-07-06 |
Other References:
JPN6012060629; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ． ３５, 1994, ６５４７-６５５０
JPN6012060631; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ４, 1994, １５７１-１５７６
JPN6012060632; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ． ３５, 1994, ２２１７-２２２０
JPN6012060634; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ３７, 1994, １４０８-１４１０
JPN6012060631; Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． ４, 1994, １５７１-１５７６
JPN6012060632; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ． ３５, 1994, ２２１７-２２２０
JPN6012060634; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ３７, 1994, １４０８-１４１０
Attorney, Agent or Firm:
Patent business corporation Odashima patent office