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Title:
1,1- AND 1,2-DISUBSTITUTED CYCLOPROPANE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS
Document Type and Number:
Japanese Patent JP2005314431
Kind Code:
A
Abstract:

To provide new 1,1- and 1,2-disubstituted cyclopropane compounds which specifically interact on central nicotine-like receptors of type α4β2.

The compound of formula (I) (the marks in the formula are specially defined). The pharmaceutical composition comprises a combination of at least one compound selected from the compound, its isomers and their adduct salts to pharmaceutically acceptable acids or bases, as an active ingredient, with one or more inactive, non-toxic and pharmaceutically acceptable media or carriers.


Inventors:
GOLDSTEIN SOLO
GUILLONNEAU CLAUDE
CHARTON YVES
LOCKHART BRIAN
LESTAGE PIERRE
Application Number:
JP2005158854A
Publication Date:
November 10, 2005
Filing Date:
May 31, 2005
Export Citation:
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Assignee:
SERVIER LAB
International Classes:
A61K31/10; A61K31/13; A61K31/133; A61K31/15; A61K31/16; A61K31/215; A61K31/22; A61K31/221; A61K31/223; A61K31/27; A61K31/40; A61K31/44; A61K31/4402; A61K31/4406; A61K31/445; A61K31/455; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/34; A61P29/00; A61P29/02; A61P43/00; C07C62/02; C07C209/00; C07C211/37; C07C213/00; C07C213/02; C07C213/06; C07C215/20; C07D295/08; C07C215/42; C07C217/44; C07C217/52; C07C219/18; C07C219/20; C07C219/24; C07C269/00; C07C269/02; C07C271/12; C07C271/22; C07C271/24; C07C271/34; C07C319/14; C07C321/28; C07C323/26; C07C323/33; C07D213/30; C07D213/38; C07D213/53; C07D213/65; C07D213/70; C07D213/80; C07D213/803; C07D295/096; C07D417/12; (IPC1-7): C07C215/42; A61K31/13; A61K31/133; A61K31/16; A61K31/221; A61K31/27; A61K31/40; A61K31/4402; A61K31/4406; A61K31/455; A61P25/14; A61P25/16; A61P25/28; A61P25/34; A61P29/00; A61P43/00; C07C62/02; C07C209/00; C07C211/37; C07C213/00; C07C215/20; C07C219/20; C07C269/00; C07C271/22; C07C271/24; C07C323/33; C07D213/30; C07D213/38; C07D213/53; C07D213/65; C07D213/70; C07D213/80; C07D213/803; C07D295/08
Domestic Patent References:
JPS58965A1983-01-06
JP3720735A
Foreign References:
FR1315433A1963-01-18
US3156725A1964-11-10
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda