Title:
11,15-O-ジアルキルプロスタグランジンE誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
Document Type and Number:
Japanese Patent JP4044967
Kind Code:
B2
Abstract:
The present invention provides 11,15-O-dialkyl prostaglandin E derivatives of formula (I) (wherein all symbols are as described in Specification), or non-toxic salts thereof or cyclodextrin clathrates thereof, processes for the preparation thereof and pharmaceutical compositions containing them as active ingredient. A compound of formula (I) binds strongly and acts on EP3 receptor which is a subtype of PGE2 receptor and therefore is useful for prevention and/or treatment of liver diseases, kidney diseases, pancreatitis, myocardial infarction etc.
Inventors:
Shuichi Ouchida
Takayuki Maruyama
Takayuki Maruyama
Application Number:
JP53414898A
Publication Date:
February 06, 2008
Filing Date:
February 10, 1998
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
C07C405/00; A61K31/5575; A61K31/557; A61P1/16; A61P1/18; A61P9/10; A61P13/12
Domestic Patent References:
| JP50030850A | ||||
| JP47042333A | ||||
| JP55115836A | ||||
| JP50069045A |
Foreign References:
| US4236027 |
Other References:
寺島孜郎、外2名,「プロスタグランジンと関連生理活性物質」, 株式会社講談社, 1981年 5月 1日, p.45-48
Kiyotaka Ohno, et.al., A Mild methylation of alcohols with Diazomethane catalyzed by Silica gel, Tetrahedron Letters, 英国, 1979年, No.45, p.4405-4406
Kiyotaka Ohno, et.al., A Mild methylation of alcohols with Diazomethane catalyzed by Silica gel, Tetrahedron Letters, 英国, 1979年, No.45, p.4405-4406
Attorney, Agent or Firm:
Kunihisa Landlord