Title:
1,1,2-TRIPHENYL-1-BUTENE DERIVATIVE
Document Type and Number:
Japanese Patent JPS6299352
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formula I (R1 and R2 are lower alkyl or together with N form a heterocyclic group; R3 is H, halogen, lower alkyl, lower alkoxy or nitro).
EXAMPLE: (Z)-2-[ 4-( 4-benzyloxyphenyl )-2-phenyl-1-butenyl ]phenoxy]-N,N-dime thylethylamine hydrochloride.
USE: It has excellent anti-estrogen activity and is useful especially for the remedy of mammary tumor and anovular sterility.
PREPARATION: The compound of formula I can be produced by reacting the alkene derivative of formula II with the benzyl halide derivative of formula III (X is halogen) in an organic solvent.
Inventors:
ASAO TETSUJI
AZUMAOKA TOSHIYUKI
TAKEDA SETSUO
TADA YUKIO
YASUMOTO SANJI
YAMADA YUJI
SAIMI NORIO
AZUMAOKA TOSHIYUKI
TAKEDA SETSUO
TADA YUKIO
YASUMOTO SANJI
YAMADA YUJI
SAIMI NORIO
Application Number:
JP23982085A
Publication Date:
May 08, 1987
Filing Date:
October 25, 1985
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD
International Classes:
A61K31/135; A61P13/02; A61P15/00; A61P35/00; C07C67/00; C07C213/00; C07C217/18; C07C217/32; C07D295/08; (IPC1-7): A61K31/135; C07C93/06; C07D295/08
Attorney, Agent or Firm:
Eiji Saegusa
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