1,12B-DISUBSTITUTED OCTAHYDROINDOLO(2,3-A)QUINOLIDINE DERIVATIVE

Title:

1,12B-DISUBSTITUTED OCTAHYDROINDOLO(2,3-A)QUINOLIDINE DERIVATIVE

Document Type and Number:

Japanese Patent JPS61249985

Kind Code:

A

Abstract:

The invention relates to new racemic and optically active 1,12b-disubstituted octahydroindolo[2,3- alquinolizine derivatives of formula (I)whereinR¹ and R² are the same or different and represent hydrogen, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or hydroxyl,R" and R⁵ are the same or different and represent hydrogen, alkyl having from to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety,R⁴ is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, andR⁶ is an electron attracting substituent, and cis and trans isomers and acid addition salts thereof.The compounds are pharmaceutically active, in particular they show an outstanding cardiovascular, e.g. selective peripheral vasodilating activity. Some of these compounds are valuable intermediates in the preparation of other, pharmaceutically active compounds.

Inventors:

CHIYABA SAANTAI
FUERENTSU SOTEI
MAARIA INTSUE
JIYUJIYANNA BAROO
JIYORUTO SONBATSUEII
EGON KAARUPAATEI
BEERA KISHIYU
KATARIN CHIYOMORU
ISHIYUTOBAAN RASUROBUSUKI
ERUJIEEBETO RAPISHIYU
RIRA FUORUGAACHIE
CHIYABA KUTSUI
RAASUROO SUPORUNIYU

Application Number:

JP8839686A

Publication Date:

November 07, 1986

Filing Date:

April 18, 1986

Export Citation:

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Assignee:

RICHTER GEDEON VEGYESZET

International Classes:

A61K31/435; A61P9/08; C07D209/14; C07D209/16; C07D401/06; C07D471/14; (IPC1-7): A61K31/435; C07D209/14; C07D471/14

Domestic Patent References:

JP54500053Y

Attorney, Agent or Firm:

Aoki Akira

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