Title:
1',2'-DIACYL-(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5883691
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of formulaI(R1, R2 are acyl).
EXAMPLE: 1',2'-Diacetyl-(6R)-5,6,7,8-tetrahydro-L-biopterin.
USE: A remedy for phenylketonurea and dihydropterin reductase deficiency.
PREPARATION: 1',2'-Diacyl-L-biopterin of formula II is hydrogenated in a solvent such as trifluoroacetic acid in the presence of a catalyst such as platinum. Immediately, the catalyst is filtered off and the filtrate is frozen with liquid nitrogen. Then, a methanol-hydrochloric acid mixture is added thereto and further ether is added to melt the frozen solution, thus separating white crystals. The precipitate is centrifuged, rinsed with a solvent and dried to give a white powder of the compound of formulaI.
Inventors:
MATSUKUSU BISUKONCHIINI
Application Number:
JP18294881A
Publication Date:
May 19, 1983
Filing Date:
November 13, 1981
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND
MATSUKUSU BISUKONCHIINI
MATSUKUSU BISUKONCHIINI
International Classes:
A61K31/495; A61K31/505; A61K31/519; A61P43/00; C07D475/04; (IPC1-7): A61K31/505; C07D475/04
Other References:
HELV.CHIM.ACT=1977
TELV.CHIM.ACT=1978
HELV.CHIM.ACT=1979
TELV.CHIM.ACT=1978
HELV.CHIM.ACT=1979
Attorney, Agent or Firm:
Sota Asahina