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Title:
1,2-DIHYDRO-3H-INDAZOL-3-ONE DERIVATIVE, ITS PRODUCTION AND PHAROMACOLOGICAL COMPOSITION CONTAINING THE DERIVATIVE AND TREATING LEUCOTRIENE MEDIATED DISEASE AND MEDICAL SYMPTOM
Document Type and Number:
Japanese Patent JPH0288560
Kind Code:
A
Abstract:

NEW MATERIAL: A compd. represented by formula I [wherein Ra is H, halogen, hydroxy, CN or 1-6C alkyl; Rb is H or 1-6C alkyl; Rc is H, 1-8C alkyl or 3-8C alkenyl; and Y is 1-8C alkyl or 3-8C alkenyl), its salt and its 1-4C alkoxycarbonyl deriv.

EXAMPLE: 1,2-Dihydro-2-methyl-4-(N-methylcarbamoyl)-3H-indazol-3-one.

USE: A riboxygenase inhibitor. Useful as a remedy of leucotriene mediated allergy symptoms, asthma, cardiovascular disorder and cerebrovascular disorder.

PROCESS: A compd. represented by formula II (Rd is a protective group) is treated to remove a protective group and, when a salt is required, the obtained compd. is reacted with a proper acid or base by a usual method to obtain the compd. represented by formula I.


Inventors:
PIEERU ANDORE REIMON BURUNOO
Application Number:
JP18066889A
Publication Date:
March 28, 1990
Filing Date:
July 14, 1989
Export Citation:
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Assignee:
ICI PHARMA
ICI PLC
International Classes:
A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/495; A61P11/00; A61P17/00; A61P27/16; A61P37/08; C07D231/56; C07D401/04; C07D401/06; C07D405/04; C07D409/04; C07D409/06; C07D413/04; C07D413/06; C07D417/04; C07D417/06; (IPC1-7): A61K31/44; A61K31/495; C07D231/56; C07D401/04; C07D405/04; C07D409/04; C07D413/04; C07D417/04
Attorney, Agent or Firm:
Toshio Yano