12BETA-HYDROXYPREGNA-1,4-DIEN-3-ONE-20ALPHA-CARBALDEHYDE AND ITS PREPARATION

Title:

12BETA-HYDROXYPREGNA-1,4-DIEN-3-ONE-20ALPHA-CARBALDEHYDE AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS58204000

Kind Code:

A

Abstract:

NEW MATERIAL:12β-Hydroxypregna-1,4-dien-3-one-20α-carbaldehyde of formula I .

USE: Useful as a synthetic raw material of corticoid steroid such as prednisolone, etc. useful as an antiphlogistic agent.

PROCESS: The compound of formula I can be prepared by culturing a bacterial strain capable of producing 12β-hydroxypregna-1,4-dien-3-one-20α-carbaldehyde using the deoxycholic acid of formula II (R is H, alkali metal or alkaline earth metal) and/or its salt as a substrate and belonging to Alcaligenes genus [e.g. Alcaligenes faecalis D4020-K15 (FERM-P No.204) which is a mutant of Alcaligenes faecalis D4020 (FERM-P No.182)] in a medium containing the compound of formula II.

More Like This:

WO/2017/119795	NOVEL LACTOBACILLUS CASEI GFC1 STRAIN, FERMENTED GINSENG EXTRACT USING STRAIN, AND PREPARATION METHOD THEREOF
WO/2005/030977	FERMENTATION METHOD FOR THE PREPARATION OF TESTOLACTONE BY FUSARIUM SPECIES

Inventors:

HARADA HIDEMI
FUMINO MASAYASU
TSUJI MASAO
ICHIHARA YOSHIHIRO

Application Number:

JP8704782A

Publication Date:

November 28, 1983

Filing Date:

May 21, 1982

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KURARAY CO

International Classes:

C12P33/16; C07J9/00; C12P33/02; C12R1/05; (IPC1-7): C07J9/00; C12P33/02; C12P33/16

Attorney, Agent or Firm:

Honda Ken

Previous Patent: PREPARATION OF GLUCOSE COMPOUND

Next Patent: MACROMOLECULAR POLYSACCHARIDE SUBSTANCE MPS-83 AND ITS USE