Title:
ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾール誘導体化合物及びこれを含有する薬剤学的組成物
Document Type and Number:
Japanese Patent JP6491393
Kind Code:
B2
Abstract:
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
Inventors:
Ek Kwan
Kim yun tae
Ichan Sik
Song Hye Sung
Guouk Dal-Yeon
Jejeun
Oh Jun Tech
Yi Chang Gong
Kim Il Hyang
Kim yun tae
Ichan Sik
Song Hye Sung
Guouk Dal-Yeon
Jejeun
Oh Jun Tech
Yi Chang Gong
Kim Il Hyang
Application Number:
JP2018505725A
Publication Date:
March 27, 2019
Filing Date:
August 04, 2016
Export Citation:
Assignee:
Chung Kung Dan Pharmaceutical Corporation
International Classes:
C07D271/10; A61K31/4245; A61K31/438; A61K31/454; A61K31/496; A61K31/5377; A61K31/541; A61K31/551; A61K31/553; A61P1/00; A61P3/00; A61P5/00; A61P9/00; A61P11/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P25/14; A61P25/18; A61P27/02; A61P31/00; A61P35/00; A61P43/00; C07D413/04; C07D413/12; C07D413/14; C07D417/12; C07D471/10; C07D491/107
Domestic Patent References:
| JP2009542752A | ||||
| JP2014524922A | ||||
| JP2011502133A | ||||
| JP2014533734A |
Foreign References:
| WO2013066835A1 | ||||
| WO2013066839A1 |
Other References:
Database REGISTRY,2006年,RN 904635-69-4, Retrieved from STN international [online] ;retrieved on 10 September 2018
Database REGISTRY,2006年,RN 904652-71-7, Retrieved from STN international [online] ;retrieved on 10 September 2018
Database REGISTRY,2006年,RN 904653-13-0, Retrieved from STN international [online] ;retrieved on 10 September 2018
Database REGISTRY,2006年,RN 904652-71-7, Retrieved from STN international [online] ;retrieved on 10 September 2018
Database REGISTRY,2006年,RN 904653-13-0, Retrieved from STN international [online] ;retrieved on 10 September 2018
Attorney, Agent or Firm:
Hayashi Ichiyoshi
Tetsuo Shiba
Takuya Saito
Iwaike Mitsuru
Kazuhiro Kosuga
Hiroshi Hayashi
Tetsuo Shiba
Takuya Saito
Iwaike Mitsuru
Kazuhiro Kosuga
Hiroshi Hayashi