NEW MATERIAL: A compound of formula I [wherein R1 is an alkyl, cycloalkyl, aryl, a heterocyclic ring; R2 is nitro, a halogen, alkyl, phenyl, etc.; R3 is alkyl, cyano and R3 can form a ring with R2; R4 is alkyl, alkenyl, phenyl, etc.; Y is a group of formula II (wherein A is H, methyl; B is NH, etc.; R13 is H, alkyl, etc.; R14 is H, alkyl, etc.)].
EXAMPLE: (1R,2S)-[1-methyl-2-methoxycarbonyl-2-(4-trisulfamoyl)]-ethyl-1,4- dihydro-2,6-dimethyl-3-nitro-4-phenylpyridine-5-carboxylate.
USE: An intermediate for a repressor of cardiovascular disturbances.
PREPARATION: For example, an aldehyde of formula II and a compound of formula IV are reacted to obtain a compound of formula V and then this compound is reacted with a compound of formula VI, or a compound of formula VII (wherein D is NH; E is 1-2H) to obtain the compound of the formula I.
MARUTEIN BETSUHEMU
RAINAA GUROOSU
JIIKUBERUTO HEBITSUSHIYU
MATEIASU SHIYURAMU
