1,5-BENZOTHIAZEPINE DERIVATIVE, CARDIOTONIC AGENT AND PRODUCTION THEREOF

Title:

1,5-BENZOTHIAZEPINE DERIVATIVE, CARDIOTONIC AGENT AND PRODUCTION THEREOF

Document Type and Number:

Japanese Patent JPH0565278

Kind Code:

A

Abstract:

PURPOSE: To provide the subject new compound having cardiotonic action, free from pulse-rate accelerating side effect and, accordingly, useful as a cardiotonic agent.

CONSTITUTION: The compound of formula I (R1 is lower alkyl or cycloalkyl; R2 is H, OH or halogen; R3 to R5 are OH, lower alkyloxy, halogen, amino, lower N-alkylamino, etc.; A is -CH2- or-CH2-O-), e.g. 8-chloro-5[-3-[2-(3,4- dimethoxyphenyl)ethyl]methylamine]propionyl-2,3,4,5-tetrahydro-1,5- benzothiazepine fumaric acid salt. The compound of formula I can be produced by reacting a compound of formula II with a compound of formula III (R' and R" are OH or lower alkyl) and reducing the obtained compound.

Inventors:

TOMIYAMA TAKESHI
TOMIYAMA ITARU
WAKABAYASHI SHUICHI
KOSAKAI KAZUHIRO
KAMIYAMA NAOTO
SEKIGUCHI JUNKO

Application Number:

JP30575991A

Publication Date:

March 19, 1993

Filing Date:

September 06, 1991

Export Citation:

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Assignee:

KOTOBUKI SEIYAKU CO LTD

International Classes:

A61K31/55; A61K31/554; A61P9/04; C07D281/10; (IPC1-7): A61K31/55; C07D281/10

Attorney, Agent or Firm:

Hideo Nagata (2 outside)

Next Patent: JPS565279