Title:
18員大環状化合物及びその類似化合物
Document Type and Number:
Japanese Patent JP5166040
Kind Code:
B2
Abstract:
The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
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Inventors:
Shoo, Youe-Kong
Won, Chang-Kou
Chiu, Yu-Hang
Romero, alex
Bubba Honey, Flaha
Sears, Pamela
Okm, franklin
Won, Chang-Kou
Chiu, Yu-Hang
Romero, alex
Bubba Honey, Flaha
Sears, Pamela
Okm, franklin
Application Number:
JP2007553073A
Publication Date:
March 21, 2013
Filing Date:
January 31, 2005
Export Citation:
Assignee:
Optimer Pharmaceuticals, Inc.
International Classes:
A61K31/7048; A61K9/107; A61K9/20; A61K9/48; A61P31/04; A61P43/00
Domestic Patent References:
| JP11504937A | ||||
| JP50111290A |
Foreign References:
| US4918174 |
Other References:
Kim L. Credito, et al.,Antimicrobial Agents and Chemotherapy,2004年,4430-4434頁
The Journal of Antibiotics,1987年,40(5),567-574頁
ARNONE A,JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1,英国,CHEMICAL SOCIETY,1987年 1月 1日,P1353-1359
The Journal of Antibiotics,1988年,41(3),308-315頁
Journal of Molecular Biology,1979年,127(1),55-72頁
The Journal of Antibiotics,1987年,40(5),567-574頁
ARNONE A,JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1,英国,CHEMICAL SOCIETY,1987年 1月 1日,P1353-1359
The Journal of Antibiotics,1988年,41(3),308-315頁
Journal of Molecular Biology,1979年,127(1),55-72頁
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki