Title:
19,26,27-トリノル-(20S)-1α-ヒドロキシビタミンD3の2α-メチルおよび2β-メチル類似体およびそれらの使用
Document Type and Number:
Japanese Patent JP2008520689
Kind Code:
A
Abstract:
This invention discloses 2alpha-methyl and 2beta-methyl analogs of 19,26,27-trinor-(20S)-1alpha-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. These compounds may also be used for the treatment or prevention of obesity.
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Inventors:
Deluca, Hector Ef
Plum, Lori Ai
Gurzaiwakutsu, Powell Kay
Claget-Darm, Margaret
Plum, Lori Ai
Gurzaiwakutsu, Powell Kay
Claget-Darm, Margaret
Application Number:
JP2007543227A
Publication Date:
June 19, 2008
Filing Date:
November 18, 2005
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C401/00; A61K31/59; A61P1/04; A61P3/04; A61P3/10; A61P11/06; A61P17/02; A61P17/06; A61P17/16; A61P19/08; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; C07F7/18
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Naoshi Nakata
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Naoshi Nakata