1H,7H-PYRAZOLO(1,5-A)PYRIMIDIN-7-ONE DERIVATIVE AND MANUFACTURE

Japanese Patent JPS60228483

A

1H,7H-Pyrazolo[1,5-a]pyrimidine-7-one derivatives of formula (I> wherein R1 is: a) C1-C6 alkyl or benzyl; b) pyridyl, unsubstituted or substituted by C1-C6 alkyl; c) phenyl, unsubstituted or substituted by one or more substituents chosen from halogen,trihalo-methyl, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, formyloxy C2-C6 alkanoyloxy, nitro, amino, formylamino and C2-C6 alkanoylamino; R2 is a) pyridyl; or b) phenyl, unsubstituted or substituted by one or more substituents chosen from halogen, trihalomethyl, nitro, C1-C6 alkoxy and C1-C6 alkyl; R3 is hydrogen or C1-C6 alkyl, unsubstituted or substituted by one or more substituents chosen from halogen, hydroxy, C1-C6 alkoxy, formyloxy, C2-C6 alkanoyloxy and the group, wherein each of R5 and R6 is independently hydrogen, C1-C6 alkyl, phenyl or benzyl, or R5 and R6, taken together with the nitrogen atom to which they are linked, forms heterocyclic ring chosen from N-imidazolyl, hexahydro-N-azepinyl, N-pyrrolidinyl, N-piperazinyl, piperidino, thiomorpholino and morpholino, each of the heterocyclic rings being unsubstituted or substituted by C1-C6 alkyl; R4 is hydrogen, halogen, C1-C6 alkyl, hydroxy, C1-C6 alkoxy, C3-C4 alkenoyloxy, formyloxy or C2-C6 alkanoyloxy; and the pharmaceutically acceptable salts thereof; are central nervous system depressants.

JIYANFUEDERIKO DORIA
KARURO PATSUSAROTSUTEI
ROBERUTO SARA
ARETSUSANDORO ROTSUSHI

JP7452785A

November 13, 1985

April 10, 1985

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ERBA CARLO SPA

A61K31/505; A61K31/535; A61K31/54; A61P25/00; A61P25/08; A61P25/20; C07D233/54; C07D487/04; (IPC1-7): A61K31/505; A61K31/535; A61K31/54; C07D487/04

Chika Takagi

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