Title:
2-アミノチアゾール誘導体、その製剤方法および使用
Document Type and Number:
Japanese Patent JP2014506897
Kind Code:
A
Abstract:
The present invention relates to the preparation of a 2-aminothiazole derivative having a structure as formula (I) and a therapeutic effect thereof for Alzheimer's disease (AD), and a therapeutic effect thereof against transplant rejection, autoimmune diseases, ischemia-reperfusion injury, chronic inflammation response, endotoxemia, and other diseases.
Inventors:
Ginger Otori Super
Shuhei
Chen Founding
Wang Yue
Cao Treasure Shuai
Yang Ka
Shuhei
Chen Founding
Wang Yue
Cao Treasure Shuai
Yang Ka
Application Number:
JP2013555731A
Publication Date:
March 20, 2014
Filing Date:
February 01, 2012
Export Citation:
Assignee:
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
International Classes:
C07D277/20; A61K31/426; A61K31/427; A61K31/428; A61K31/4439; A61K31/496; A61P3/10; A61P25/00; A61P25/28; A61P37/06; A61P43/00; C07D277/40; C07D277/82; C07D401/12; C07D417/06
Domestic Patent References:
| JPH07502014A | 1995-03-02 | |||
| JPS5461172A | 1979-05-17 | |||
| JPH11505814A | 1999-05-25 | |||
| JP2009531370A | 2009-09-03 |
Foreign References:
| WO2008101029A2 | 2008-08-21 | |||
| WO2010129954A1 | 2010-11-11 | |||
| US3957766A | 1976-05-18 | |||
| WO2011115998A2 | 2011-09-22 |
Other References:
JPN6014042798; Ｗｅｎ-Ｔｉｎｇ Ｚｈａｎｇ ｅｔ ａｌ．: 'Ｄｅｓｉｇｎ， Ｓｙｎｔｈｅｓｉｓ， ａｎｄ Ｃｙｔｏｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔ ｏｆ ２-Ａｍｉｎｏｔｈｉａｚｏｌｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｐｏｔｅｎｔ Ｐｏｌｙ（ＡＤＰ-Ｒｉｂｏｓｅ）' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ５２（３）, 2009, ｐ． ７１８-７２５
JPN6014042802; Ｃｈｒｉｓｔｉｎａ Ｐａｐａｄｏｐｏｕｌｏｕ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｎｅｗ ｔｈｉａｚｏｌｙｌ／ｂｅｎｚｏｔｈｉａｚｏｌｙｌ-ａｍｉｄｅｓ， ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ４-ｐｈｅｎｙｌ-' Ｆａｒｍａｃｏ ６０（１１-１２）, 2005, ｐ． ９６９-９７３
JPN6014042806; Ｃ． Ｌａｎｄｒｅａｕ ｅｔ ａｌ．: '２-Ａｍｉｎｏ-４-ｄｉｍｅｔｈｙｌａｍｉｎｏ-１-ｔｈｉａ-３-ａｚａｂｕｔａｄｉｅｎｅｓ ａｓ ｐｒｅｃｕｒｓｏｒｓ ｏｆ ｔｈｉａｚｏｌｅｓ' Ｐｈｏｓｐｈｏｒｕｓ， Ｓｕｌｆｕｒ ａｎｄ Ｓｉｌｉｃｏｎ １７７（１１）, 2002, ｐ． ２６５１-２６５９
JPN6014042798; Ｗｅｎ-Ｔｉｎｇ Ｚｈａｎｇ ｅｔ ａｌ．: 'Ｄｅｓｉｇｎ， Ｓｙｎｔｈｅｓｉｓ， ａｎｄ Ｃｙｔｏｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔ ｏｆ ２-Ａｍｉｎｏｔｈｉａｚｏｌｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｐｏｔｅｎｔ Ｐｏｌｙ（ＡＤＰ-Ｒｉｂｏｓｅ）' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ５２（３）, 2009, ｐ． ７１８-７２５
JPN6014042802; Ｃｈｒｉｓｔｉｎａ Ｐａｐａｄｏｐｏｕｌｏｕ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｎｅｗ ｔｈｉａｚｏｌｙｌ／ｂｅｎｚｏｔｈｉａｚｏｌｙｌ-ａｍｉｄｅｓ， ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ４-ｐｈｅｎｙｌ-' Ｆａｒｍａｃｏ ６０（１１-１２）, 2005, ｐ． ９６９-９７３
JPN6014042806; Ｃ． Ｌａｎｄｒｅａｕ ｅｔ ａｌ．: '２-Ａｍｉｎｏ-４-ｄｉｍｅｔｈｙｌａｍｉｎｏ-１-ｔｈｉａ-３-ａｚａｂｕｔａｄｉｅｎｅｓ ａｓ ｐｒｅｃｕｒｓｏｒｓ ｏｆ ｔｈｉａｚｏｌｅｓ' Ｐｈｏｓｐｈｏｒｕｓ， Ｓｕｌｆｕｒ ａｎｄ Ｓｉｌｉｃｏｎ １７７（１１）, 2002, ｐ． ２６５１-２６５９
JPN6014042802; Ｃｈｒｉｓｔｉｎａ Ｐａｐａｄｏｐｏｕｌｏｕ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｎｅｗ ｔｈｉａｚｏｌｙｌ／ｂｅｎｚｏｔｈｉａｚｏｌｙｌ-ａｍｉｄｅｓ， ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ４-ｐｈｅｎｙｌ-' Ｆａｒｍａｃｏ ６０（１１-１２）, 2005, ｐ． ９６９-９７３
JPN6014042806; Ｃ． Ｌａｎｄｒｅａｕ ｅｔ ａｌ．: '２-Ａｍｉｎｏ-４-ｄｉｍｅｔｈｙｌａｍｉｎｏ-１-ｔｈｉａ-３-ａｚａｂｕｔａｄｉｅｎｅｓ ａｓ ｐｒｅｃｕｒｓｏｒｓ ｏｆ ｔｈｉａｚｏｌｅｓ' Ｐｈｏｓｐｈｏｒｕｓ， Ｓｕｌｆｕｒ ａｎｄ Ｓｉｌｉｃｏｎ １７７（１１）, 2002, ｐ． ２６５１-２６５９
JPN6014042798; Ｗｅｎ-Ｔｉｎｇ Ｚｈａｎｇ ｅｔ ａｌ．: 'Ｄｅｓｉｇｎ， Ｓｙｎｔｈｅｓｉｓ， ａｎｄ Ｃｙｔｏｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔ ｏｆ ２-Ａｍｉｎｏｔｈｉａｚｏｌｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｐｏｔｅｎｔ Ｐｏｌｙ（ＡＤＰ-Ｒｉｂｏｓｅ）' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ５２（３）, 2009, ｐ． ７１８-７２５
JPN6014042802; Ｃｈｒｉｓｔｉｎａ Ｐａｐａｄｏｐｏｕｌｏｕ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｎｅｗ ｔｈｉａｚｏｌｙｌ／ｂｅｎｚｏｔｈｉａｚｏｌｙｌ-ａｍｉｄｅｓ， ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ４-ｐｈｅｎｙｌ-' Ｆａｒｍａｃｏ ６０（１１-１２）, 2005, ｐ． ９６９-９７３
JPN6014042806; Ｃ． Ｌａｎｄｒｅａｕ ｅｔ ａｌ．: '２-Ａｍｉｎｏ-４-ｄｉｍｅｔｈｙｌａｍｉｎｏ-１-ｔｈｉａ-３-ａｚａｂｕｔａｄｉｅｎｅｓ ａｓ ｐｒｅｃｕｒｓｏｒｓ ｏｆ ｔｈｉａｚｏｌｅｓ' Ｐｈｏｓｐｈｏｒｕｓ， Ｓｕｌｆｕｒ ａｎｄ Ｓｉｌｉｃｏｎ １７７（１１）, 2002, ｐ． ２６５１-２６５９
Attorney, Agent or Firm:
Takahiro Ozaki