Title:
2-アザプリン化合物及びその使用
Document Type and Number:
Japanese Patent JP4202646
Kind Code:
B2
Abstract:
Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.
Inventors:
Sarah, Frank
Rose Meyer, Helmut
Juvine Berger, Enno
Heindle, Dieter
Bergmann, Frank
Rose Meyer, Helmut
Juvine Berger, Enno
Heindle, Dieter
Bergmann, Frank
Application Number:
JP2001519712A
Publication Date:
December 24, 2008
Filing Date:
August 28, 2000
Export Citation:
Assignee:
BOEHRINGER MANNHEIM GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
International Classes:
C07H21/00; G01N33/53; C07H19/04; C07H19/10; C07H19/20; C12N15/09; C12N15/113; C12P19/34; C12Q1/08; C12Q1/68; G01N33/566; C12Q1/6813
Other References:
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Biochim. Biophys. Acta,1978年,Vol.520,441-451
MONTGOMERY J A,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1975年,V18N6,P564-567
J A CARBON,JOURNAL OF ORGANIC CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1960年 5月 3日,V25N4,P579-582
M ACEDO,JOURNAL OF ORGANIC CHEMISTRY,1995年,V60N20,P6262-6269
D FERNANDEZ-FORNER,TETRAHEDRON,1991年,V47N42,P8917-8930
J C BUSSOLARI,BIOORGANIC AND MEDICINAL CHEMISTRY,1996年,V4N10,P1725-1731
Z KAZIMIERCZUK,LIEBIGS ANNALEN DER CHEMIE,ドイツ,VERLAG CHEMIE GMBH,1990年,N7,P647-651
Biochim. Biophys. Acta,1978年,Vol.520,441-451
MONTGOMERY J A,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1975年,V18N6,P564-567
J A CARBON,JOURNAL OF ORGANIC CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1960年 5月 3日,V25N4,P579-582
M ACEDO,JOURNAL OF ORGANIC CHEMISTRY,1995年,V60N20,P6262-6269
D FERNANDEZ-FORNER,TETRAHEDRON,1991年,V47N42,P8917-8930
J C BUSSOLARI,BIOORGANIC AND MEDICINAL CHEMISTRY,1996年,V4N10,P1725-1731
Z KAZIMIERCZUK,LIEBIGS ANNALEN DER CHEMIE,ドイツ,VERLAG CHEMIE GMBH,1990年,N7,P647-651
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima