Title:
2-ACYLBENZCYANAMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS55143959
Kind Code:
A
Abstract:
NEW MATERIAL:The title compound of the formula I (R1 is H, alkyl, alkoxy, or halogen; R2 is alkyl, cycloalkyl, or haloalkyl; R3 is alkyl, aralkyl, phenyl, or halophenyl).
EXAMPLE: 2-(N-cyanoisopropylamino)-4-methylbenzophenone.
USE: Useful as medicines for men and animals, and as intermediates for the synthesis of antiinflammatory agents, quinazolin-2-ones, due to the antiinflammatory effects.
PROCESS: A compound of formula II is reacted with a cyanogen halogenide, e.g. cyanogen chloride or bromide, in the presence of a salt, preferably potassium carbonate or sodium hydrogencarbonate, usually in an inert solvent, e.g. chloroform, at about 60W80°C, to give the title compound of formula I.
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Inventors:
ADACHI MAKOTO
HIROSE KATSUMI
SUGASAWA TSUTOMU
HIROSE KATSUMI
SUGASAWA TSUTOMU
Application Number:
JP5217679A
Publication Date:
November 10, 1980
Filing Date:
April 26, 1979
Export Citation:
Assignee:
SHIONOGI SEIYAKU KK
International Classes:
A61K31/275; A61P29/00; C07C67/00; C07C239/00; C07C261/04; (IPC1-7): A61K31/275; C07C125/08
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