Title:
2-AMINOPYRIMIDINE 3-OXIDE DERIVATIVE, AND COMPOSITION CONTAINING NEW COMPOUND DERIVED FROM THE 3-OXIDE DERIVATIVE FOR RETARDING HAIR LOSS, AND FOR INDUCING AND STIMULATING HAIR GROWTH
Document Type and Number:
Japanese Patent JPH03118372
Kind Code:
A
Abstract:
NEW MATERIAL: A compound of formula I [R is H, a 1-8C alkyl, etc.; X is H, formula II (R1 and R2 are each H, a 1-12C alkyl, a 2-12C alkenyl, etc.) or OR3 (R3 is a 1-12C alkyl, phenyl, etc.); Y is O or OSO3; R' is H or formula III (R5 is a 1-4C alkyl), etc.].
EXAMPLE: 2-Amino-4-methyl-6-piperidinopyrimidine 3-oxide.
USE: The subject compound has induction and stimulation activity for hair growth, and retardation activity for hair loss. It is useful in treatment of alopecia, alopecia areata, hair loss, and desquamating dermatitis.
PREPARATION: A compound of formula I is obtained by hydrogenolysis of a compound of formula IV (Z is a halogen, sulfonate, a substd. phenoxy, etc.) in a conventional manner.
Inventors:
DEIDEIE DEYUFUTERU
FURANSOWAAZU ESUTORADEIE
KANCHINO GAETANI
MISHIERU OTSUKOO
FURANSOWAAZU ESUTORADEIE
KANCHINO GAETANI
MISHIERU OTSUKOO
Application Number:
JP22453190A
Publication Date:
May 20, 1991
Filing Date:
August 28, 1990
Export Citation:
Assignee:
OREAL
International Classes:
A61K8/00; A61K8/33; A61K8/34; A61K8/36; A61K8/365; A61K8/37; A61K8/39; A61K8/42; C07D239/47; A61K8/49; A61K31/41; A61K31/505; A61K31/517; A61K31/519; A61K31/535; A61P17/00; A61P17/14; A61Q5/00; A61Q5/02; A61Q7/00; C07D239/42; C07D239/46; C07D239/48; C07D239/84; C07D239/95; C07D498/04; (IPC1-7): A61K7/06; A61K31/41; A61K31/505; A61K31/535; C07D239/47; C07D239/48; C07D239/95; C07D498/04
Attorney, Agent or Firm:
Heikichi Odashima