PURPOSE: To provide the subject compound which has antagonism activity of α1-type adrenergic receptor in lower urinary tract and is useful for curing diseases including hypertonia of urinary tract.
CONSTITUTION: The compound of formula I, e.g. 2-[[3-[4-(4-fluorophenoxy)-1- piperidyl]propyl]amino]pyrimidine-4-carboxamide, is obtained by allowing an amine of formula II and 2-chloropyrimidine-4-carboxamide of formula III to react with each other in an aprotic solvent (e.g. DMF) and in the presence of a base (e.g. K2CO3) at 20-40°C. It is useful especially for curing benign prostatic hypertrophy, urinary disturbance and pollakiuria. In the formula I, (m) is 0, 1; (q) is 1, 2; (n) is 2, 3; R1 is H, methyl; X is H, F, Cl, methoxy, methyl, isopropyl.
KURISUCHIYAN MAROWAZERU
BENOWA MARABOO
