Title:
2-(2-AMINOTHIAZOLYL)-2-HYDROXYIMINOACETIC ACID DERIVATIVE AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS62181248
Kind Code:
A
Abstract:
New cephalosporins are of formula (I) In the formula R and R1 are both H or both hydrolysable or hydrogenolysable gps. or R1 can also be opt. substd. 1-4C alkyl, A is H or an equiv. of an alkali(ne earth) metal or an amine. (I) have antibacterial activity against Gram-positive and -negative bacteria, esp. penicillin-resistant Staphylococci, E.coli, Klebsiella, Salmonella and Proteus spp. A typical cpd. is 3-acetoxymethyl-7-(2-(2-tritylamino-4-thiazolyl)-2-tritylhydroxyi- mino-acetamido)-3-cephem-4-carboxylic acid. In an example, this is prepd. starting from ethyl gamma-chloro-alpha-oximinoacetyl-acetate.
Inventors:
RUNE EEMU
ANDORE RIYUTSUTSU
ANDORE RIYUTSUTSU
Application Number:
JP519587A
Publication Date:
August 08, 1987
Filing Date:
January 14, 1987
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
C07D277/20; A61K31/545; A61K31/546; A61P31/04; C07C67/00; C07C239/00; C07C251/32; C07D277/38; C07D277/40; C07D277/42; C07D417/12; C07D501/20; C07D501/34; C09D175/04; (IPC1-7): C07C131/00; C07D277/40; C07D501/20
Domestic Patent References:
| JPS4727991A | ||||
| JPS484487A |
Attorney, Agent or Firm:
Motohiro Kurauchi