2-ARYL SUBSTITUTED HETEROCYCLIC COMPOUND FOR ANTIALLERGIC AND ANTIINFLAMMATORY AGENT

Title:

2-ARYL SUBSTITUTED HETEROCYCLIC COMPOUND FOR ANTIALLERGIC AND ANTIINFLAMMATORY AGENT

Document Type and Number:

Japanese Patent JPH01143856

Kind Code:

A

Abstract:

NEW MATERIAL: A compd. of formula I [X is CR4, N; Y is formula II (R4 is H, a lower alkyl), O, S, NR4, etc.; Z is (CH2)nO ((n) is 0 to 5), (CH2)nS, C≡C, etc.; R1 is formula III (R5 is a lower alkyl, a monofluorolower alkyl, etc.), etc.; R2 is H, a lower alkyl, a lower alkoxy, etc.; R3 is formula IV ((m) is 1 to 15; W is a bond, O, S, N-R3) etc.] and its salt.

EXAMPLE: 1,1,1-Trifluoro-N-[3-[[2-(4-methoxyphenyl)-5-methyl-4- oxazolyl]methoxy]phenyl]methanesulfonamide.

USE: An antiallergic and antiinflammatory agent.

PROCESS: The compd. of formula I (R1 = formula III) is obtd. by sulfonylating a compd. of formula V by using a sulfonyl halide (more preferably sulfonyl chloride or sulfonic anhydride) in accordance with the reaction formula.

Inventors:

JIYON HENRII MASEERU
RAINHORUDO HANSU UIRUHERUMU BE
ANSONII FURANKU KUREFUTO ZA SA

Application Number:

JP24890088A

Publication Date:

June 06, 1989

Filing Date:

September 30, 1988

Export Citation:

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Assignee:

AMERICAN HOME PROD

International Classes:

A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4418; A61P29/00; A61P37/08; A61P43/00; C07C51/00; C07C57/30; C07C59/64; C07C63/331; C07C65/21; C07C67/00; C07C69/618; C07C69/76; C07C213/00; C07C215/30; C07C217/18; C07C229/38; C07C229/42; C07C229/54; C07C239/20; C07C241/00; C07C243/32; C07C243/34; C07C309/80; C07C243/38; C07C253/00; C07C255/50; C07C255/54; C07C259/06; C07C313/00; C07C317/32; C07C317/36; C07C317/44; C07C323/32; C07C323/43; C07C323/44; C07C323/49; C07C323/62; C07C323/65; C07D213/30; C07D239/26; C07D241/12; C07D263/32; C07D277/22; C07D277/24; C07D277/28; C07D277/32; C07D307/40; C07D413/12; C07D417/12; C12N9/99; (IPC1-7): A61K31/42; A61K31/425; A61K31/44; C07; C07C57/30; C07C59/64; C07C63/331; C07C65/21; C07C69/618; C07C69/76; C07C91/16; C07C93/14; C07C101/42; C07C101/447; C07C101/50; C07C103/76; C07C109/10; C07C121/60; C07C121/75; C07C143/70; C07D213/30; C07D239/26; C07D241/12; C07D263/32; C07D277/24; C07D307/40; C07D417/12

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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