2-AZETIDINONE DERIVATIVE - YAMANOUCHI PHARMA CO LTD

Title:

2-AZETIDINONE DERIVATIVE

Document Type and Number:

Japanese Patent JPS58206589

Kind Code:

A

Abstract:

NEW MATERIAL:A compound of formula I {R1 is H or lower alkyl; M is H or cation; X is -(CH2)n- (n is an integer 1W4) or >C=N-O-R2 [R2 is lower alkyl or formula II (R3 and R4 are H or lower alkyl)]}.

EXAMPLE: Potassium 3(S)-3-( 2-amino-4-thiazolylacetamido )-2-zetidinone-1-oxysulfonate of formula III.

USE: An excellent antimicrobial agent effective against Gram-positive and Gram- negative bacteria, particularly the Gram-negative bacteria.

PROCESS: A compound of formula IV, e.g. (3S)-3-amino-2-azetidinone-1-oxysulfonic acid, is reacted with a compound of formula V (or a reactive derivative), e.g. 2-amino-4-thiazolyacetic acid, preferably in an organic solvent, e.g. dimethylformamide (DMF), at room temperature in the presence of a base, e.g. triethylamine.

More Like This:

JPH04234885	2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND PROCESS FOR PRODUCING THE SAME
JPS5675464	MANUFACTURE OF NNALPHAAALKOXYALKYLLCARBOXYLIC ACID AMIDE
WO/2004/000803	CATIONICALLY SUBSTITUTED DIPHENYL AZETIDINONES, METHOD FOR THEIR PRODUCTION, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF

Inventors:

KOUDA AKIO
MAEDA TETSUYA
YAMAZAKI ATSUKI
TSUKAMOTO SHINICHI
NAGANO YOSHINOBU

Application Number:

JP8929582A

Publication Date:

December 01, 1983

Filing Date:

May 26, 1982

Export Citation:

Click for automatic bibliography generation Help

Assignee:

YAMANOUCHI PHARMA CO LTD

International Classes:

C07D205/08; A61K31/397; A61K31/425; A61P31/04; C07D205/085; C07D417/12; (IPC1-7): A61K31/425; C07D417/12

Attorney, Agent or Firm:

Kiyoya Fujino

Previous Patent: ANTIULCEROUS 2-GUANIDINO-4-(2-SUBSTITUTED- AMINO-4-IMIDAZOLYL)THIAZOLES AND MANUFACTURE

Next Patent: 2-ARYLTETRAAZAINDENE COMPOUND