Title:
2-CARBAMIMIDOYL-6-SUBSTITUTED-1-CARBADETHIAPENE- 2-EM-3-CARBOXYLIC ACIDS
Document Type and Number:
Japanese Patent JPS5795989
Kind Code:
A
Abstract:
Disclosed are 2- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: wherein R@, and R@ are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; A ist a direct, single bond connecting the indicated S and C atoms, or A is a cyclic or acyclic connecting group selected, inter alia, from alkyl, cycloalkyl, aryl, heteroaryl, heteroalkyl; R@ and R@, which define the carbamimidoyl function are, inter alia, independently selected from hydrogen, alkyl, aryl; additionally, said carbamimidoyl is characterized by cyclic structures achieved by the joinder of the two nitrogen atoms via their substituents and by their joinder to connecting group A; additionally, <> are disclosed by quaternization of one of the nitrogen atoms of said carbamimidoyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; and pharmaceutical compositions comprising such compounds.
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Inventors:
BAATON JII KURISUTENSEN
DEIBUITSUDO BII AARU JIYONSUTO
SUUZAN EMU SHIYUMITSUTO
DEIBUITSUDO BII AARU JIYONSUTO
SUUZAN EMU SHIYUMITSUTO
Application Number:
JP16438981A
Publication Date:
June 15, 1982
Filing Date:
October 16, 1981
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/397; A61K31/40; A61P31/04; C07D477/20; C07D487/04; C07D487/10; C07D519/00; C07D477/00; (IPC1-7): A61K31/40; A61K31/415; A61K31/44; A61K31/445; A61K31/495; A61K31/505; A61K31/535; C07D487/04; C07D487/10; C07D519/00
Domestic Patent References:
| JPS5533494A | 1980-03-08 | |||
| JPS5466697A | 1979-05-29 | |||
| JPS5466696A | 1979-05-29 | |||
| JPS579783A | 1982-01-19 | |||
| JPS5649383A | 1981-05-02 | |||
| JPS5622787A | 1981-03-03 | |||
| JPS56154484A | 1981-11-30 | |||
| JPS565478A | 1981-01-20 | |||
| JPH0471913A | 1992-03-06 |