NEW MATERIAL: A compound of formula I (R is H or CH3; R1 and R2 are each H, methyl, ethyl, etc.; Ra, Rb, Rc and Rd are each CF3, halogen, C1-4 alkoxy, etc.; Y is COOH, ester etc.; formula II is a 5 to 6 membered monocyclic aromatic hydrocarbyl, etc.; Het is a 4 to 7 membered monocyclic aliphatic hydrocarbyl (one of the ring carbon atom is replaced by nitrogen atom, etc.), etc.).
USE: Antibacterial agents.
PROCESS: For example, a phenylcarbapenem derivative of formula III is treated with methanesulfonyl chloride, so that the hydroxy group in the molecule is sulfonated. The product is reacted with NaI to give an iodide of formula IV. The product is then reacted with an N-containing aromatic hydrocarbon of formula V to give the phenylcarbapenem compound of formula I.
DEIBUITSUDO EE MUTAADO
TOOMASU ENU ZARUTSUMAN
