Title:
2-PHENYL-SUBSTITUTED-1-PHTHALAZONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5524134
Kind Code:
A
Abstract:
NEW MATERIAL:2-Phenyl-substituted-1-phthalazone of formula I (R1, R2 are lower alkyl; R3 is alkyl; R4 is H, halogen, alkyl, alkoxy; R5 is halogen, alkyl, alkoxy, carboxyl, alkoxycarbonyl).
EXAMPLE: 7-Ethoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-2-(0-methoxyphenyl)-1- phthalazone.
USE: Remedy and prophylaxis for thrombosis, temporary cardiac ischemia, cardiac infarction, etc., effective to suppress the platelet agglutination caused by arachidonic acid.
PROCESS: The compound I is prepared by reducing a reactive derivative of a carboxylic acid II with boron hydride complex compound in a solvent, and if necessary, hydrolyzing the product. The compound II is a novel compound and can be prepared from a compound III.
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Inventors:
ISHIKAWA MASAYUKI
EGUCHI MASAO
TANAKA HIROMICHI
ITOU SHIGERU
TAKASHIMA YOSHIMI
KOBAYASHI MASAHIKO
EGUCHI MASAO
TANAKA HIROMICHI
ITOU SHIGERU
TAKASHIMA YOSHIMI
KOBAYASHI MASAHIKO
Application Number:
JP9718678A
Publication Date:
February 21, 1980
Filing Date:
August 11, 1978
Export Citation:
Assignee:
MASAYUKI ISHIKAWA
International Classes:
A61K31/50; A61K31/502; A61P7/02; A61P9/10; C07D237/32; (IPC1-7): A61K31/50; C07D237/32