Title:
2-PIPERAZINONE DERIVATIVE AND USE THEREOF
Document Type and Number:
Japanese Patent JP3125212
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new safe compound, having inhibiting actions on cell adhesion and low toxicity and useful for preventing and treating acute cardiac infarction, cerebral apoplexy, arteriosclerosis, etc.
SOLUTION: This compound of formula I [G is amidino or amino; D is a spacer of 2-6 atomic chains in which a hetero-atom and/or a 5- to a 6-membered ring may intermediate; R1 is H, benzyl, etc.; R2 and R3 are each a residue after removing CH(NH2)COOH from an α-amino acid or R1 and R2 may form a 5- or a 6-membered ring with the adjacent N or C; X is H or a lower alkyl; Z is a group capable of forming an anion or a group convertible thereinto in vivo]] or its salt [except (S)-4-(4-amidinobenzoylglycyl)-3- methoxycarbonylmethyl-2oxopiperazine-1-acetic acid or its salt], e.g. (S)-4-(4- aminobenzoylglycyl)-2-oxopiperazine-1,3-diacetic acid. The compound is obtained by condensing, e.g. a compound of formula II with a compound of formula III.
Inventors:
Hirosada Sugihara
Zenichi Terashita
Zenichi Terashita
Application Number:
JP34640996A
Publication Date:
January 15, 2001
Filing Date:
December 26, 1996
Export Citation:
Assignee:
Takeda GmbH
International Classes:
C07D241/08; A61K31/495; A61K31/496; A61P7/02; A61P35/00; A61P43/00; C07D401/12; C07D403/12; C07D417/12; (IPC1-7): C07D241/08; A61K31/495; A61K31/496; A61P7/02; C07D401/12; C07D403/12; C07D417/12
Domestic Patent References:
| JP63258894A | ||||
| JP578390A |
Other References:
【文献】米国特許4251438(US,A)
Attorney, Agent or Firm:
Shuichi Takahashi (2 outside)