Title:
ステアロイル-CoAデサチュラーゼのインヒビターとして使用するための二環式窒素含有複素環化合物
Document Type and Number:
Japanese Patent JP2011516546
Kind Code:
A
Abstract:
The present invention discloses bicyclic nitrogen-containing heterocyclic compounds for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.
Inventors:
Coulton, Dmitry
Zabrokie, Jeff
Park Hill, Eric
Grushkov, Andrey
Basilevich, Natalia
Gilberstein, Timur
Ivanov, Alexei
Chisholm, Jeffrey
Zabrokie, Jeff
Park Hill, Eric
Grushkov, Andrey
Basilevich, Natalia
Gilberstein, Timur
Ivanov, Alexei
Chisholm, Jeffrey
Application Number:
JP2011503949A
Publication Date:
May 26, 2011
Filing Date:
April 10, 2008
Export Citation:
Assignee:
Gilead Sciences, Inc.
International Classes:
C07D241/44; A61K31/498; A61K31/4985; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P35/00; A61P43/00; C07D471/04
Domestic Patent References:
| JP2010523653A | 2010-07-15 | |||
| JP2010505881A | 2010-02-25 |
Foreign References:
| US20040019210A1 | 2004-01-29 | |||
| WO2002076954A1 | 2002-10-03 | |||
| WO1999050254A1 | 1999-10-07 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita