Title:
20-ヒドロキシエイコサテトラエン酸産生阻害剤
Document Type and Number:
Japanese Patent JP4120401
Kind Code:
B2
Abstract:
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof. Äwherein R<1> represents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR<5>; and R<2> to R<5> are the same or different and each represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a trifluoromethyl group or a halogen atom.Ü There is provided a drug which inhibi ts an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.
Inventors:
Masakazu Sato
Noriyuki Miyata
Takaaki Ishii
Yuko Matsunaga
Amada Hideaki
Noriyuki Miyata
Takaaki Ishii
Yuko Matsunaga
Amada Hideaki
Application Number:
JP2002585375A
Publication Date:
July 16, 2008
Filing Date:
April 26, 2002
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
International Classes:
C07C259/14; A61K31/136; A61K31/155; A61K31/395; A61K31/402; A61K31/438; A61K31/4418; A61K31/4427; A61K31/444; A61K31/451; A61K31/4525; A61K31/4545; A61K31/47; A61K31/495; A61K31/496; A61K31/497; A61K31/5355; A61K31/5375; A61K31/5377; A61K31/54; A61K31/55; A61P9/00; A61P9/10; A61P13/12; A61P43/00; C07D207/20; C07D211/22; C07D211/46; C07D211/60; C07D211/62; C07D211/70; C07D213/74; C07D213/75; C07D215/06; C07D217/04; C07D265/30; C07D295/12; C07D295/13; C07D295/135; C07D295/15; C07D295/16; C07D295/18; C07D401/04; C07D491/10; C07D491/113
Domestic Patent References:
| JP57120575A |
Foreign References:
| WO2000046184A1 | ||||
| EP0132881A1 |
Attorney, Agent or Firm:
Tomizo Kitagawa