Title:
20-SPIROXANE STEROID, MANUFACTURE AND MEDICINE
Document Type and Number:
Japanese Patent JPS59205400
Kind Code:
A
Abstract:
(5 alpha )-20-spirox-1-en-3-ones (I) and 17-hydroxy-5 alpha ,17 alpha -pregn-1-en-3-ones (II) of the formulae (I) and +TR (II) in which X represents O or H2, R2 represents O and R1 represents OH, OMe, OAlk, NH2, NHR3, NR3R4, or R2 represents H2 and R1 represents OH, OAlk, OAr, OAralk or OAc, in which R3, R4 and Alk represent lower alkyl, Me represents a metal atom or metal equivalent or the cation of an organic base, Ar represents monocyclic aryl, Aralk represents monocyclic aryl-lower alkyl, and Ac represents lower alkanoyl, monocyclic aroyl, lower alkylsulphonyl or monocyclic arylsulphonyl, it being possible for R3 together with R4 also to represent a lower alkylene group optionally interrupted by a hetero atom, are manufactured by known analogy processes. They exhibit an aldosterone-antagonistic action and can therefore be used, for example, as potassium-conserving diuretics, optionally together with another electrolyte-non-specific diuretic or saluretic.
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Inventors:
YURUGEN GUROBU
YAROSURAFU KARUBODA
YAROSURAFU KARUBODA
Application Number:
JP7189984A
Publication Date:
November 20, 1984
Filing Date:
April 12, 1984
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K31/58; A61K31/585; A61K45/06; A61P7/10; C07J21/00; C07J71/00; (IPC1-7): A61K31/585; C07J71/00
Attorney, Agent or Firm:
Aoki Akira