バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法

Japanese Patent JP6410710

B2

The present invention relates to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-l,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide and polymorphic forms and pharmaceutical compositions thereof for use in the treatment of cancer in combination with immunotherapy, for use in the treatment of conditions associated with oxidative stree caused by mitochondrial dysfunction and for use in the treatment of seizure disorders.

JPH0618787	[Title of the Invention] A transdermal absorption promoter and a transdermal preparation using the same.
JP2009062322	HEPATOCYTE REGENERATION PROMOTOR
WO/2021/139395	HIGH-EFFICIENCY LOW-TOXICITY ANTI-CANCER COMPOUND SYNTHESIZED BY AUTOCATALYSIS IN CELLS AND LIVING BODIES AND SYNTHESIS METHOD FOR ANTI-CANCER COMPOUND

Anderson Eric
Decker Andrea
Ryu Xiao Fong

JP2015509119A

October 24, 2018

April 24, 2013

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Riata Pharmaceuticals, Inc.

C07J63/00; A61K9/06; A61K9/08; A61K9/10; A61K31/275; A61K31/337; A61K31/513; A61K47/44; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P11/00; A61P11/06; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P17/14; A61P17/18; A61P19/02; A61P27/02; A61P27/06; A61P27/14; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08

JP2011518191A
JP2010536754A
JP2011509941A
JP2006515859A

WO2009146216A1
WO2008111497A1

化学大辞典5,共立出版株式会社,1989年,縮刷版第32刷,第630-633頁
科学大辞典,丸善株式会社,2005年,第2版,第902-903頁

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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