Title:
2,2-置換1,1-ビ-2-ナフトール触媒の存在下での不斉メチルアリル化方法
Document Type and Number:
Japanese Patent JP2014514273
Kind Code:
A
Abstract:
Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
Inventors:
Re, wenge
Ryu, Gee-Hui
Senana Yake, Chris Hugh
Chan, Yonda
Ryu, Gee-Hui
Senana Yake, Chris Hugh
Chan, Yonda
Application Number:
JP2013557796A
Publication Date:
June 19, 2014
Filing Date:
March 06, 2012
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07C29/38; C07B53/00; C07C33/48; C07C37/055; C07C39/38; C07B61/00
Domestic Patent References:
| JP2002356454A | 2002-12-13 | |||
| JP2009215240A | 2009-09-24 |
Foreign References:
| WO2010011314A1 | 2010-01-28 | |||
| US20030191335A1 | 2003-10-09 | |||
| WO2004096753A1 | 2004-11-11 |
Other References:
JPN6015037587; ＢＡＲＮＥＴＴ，Ｄ．Ｓ． ｅｔ ａｌ．: Ａｎｇｅｗａｎｄｔｅ Ｃｈｅｍｉｅ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｅｄｉｔｉｏｎ Ｖｏｌ．４８, 2009, ｐ．８６７９-８６８２
JPN6015037588; ＢＡＲＮＥＴＴ，Ｄ．Ｓ． ｅｔ ａｌ．: Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３， Ｎｏ．１５, 2011, ｐ．４０２０-４０２３
JPN6015037588; ＢＡＲＮＥＴＴ，Ｄ．Ｓ． ｅｔ ａｌ．: Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３， Ｎｏ．１５, 2011, ｐ．４０２０-４０２３
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Keiko Morita
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Keiko Morita