Title:
2,3-DIHYDROBENZOFURAN DERIVATIVE
Document Type and Number:
Japanese Patent JPH1135568
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject novel compound that manifests strong cell- protecting action against the cytotoxicity caused by oxidized LDL in the kidney- originating cells and is useful for treatment or prevention of chronic renal failure and diabetic nephropathy and as an internal organ preservative. SOLUTION: This compound is represented by the formula (R1 is H, an acyl which may be substituted; R2 -R4 are each H, a lower alkyl, a lower alkenyl where both of them are not t-butyl, simultaneously; R<5> and R<6> are each H, an alkyl which may be substituted), typically 4,7-di -t-butyl-5 -hydroxy-2, 3- dihydrobenzofuran. This compound is prepared by adding dropwise methanesulfonic acid to a solution of 4-t -butyl-5 -hydroxy-2, 3-dihydrobenzofuran in a mixture of t-butyl alcohol with chloroform followed by extraction, washing and concentration of the product.
Inventors:
ISHIKAWA AKIRA
KATO YOSHIAKI
TAMURA KUNIO
TAKASHIMA YOSHIAKI
SHINSHI OSAMU
KATO YOSHIAKI
TAMURA KUNIO
TAKASHIMA YOSHIAKI
SHINSHI OSAMU
Application Number:
JP14085598A
Publication Date:
February 09, 1999
Filing Date:
May 22, 1998
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07D307/79; A01N1/02; A01N43/12; A61K31/34; A61K31/343; A61P13/02; A61P15/00; C07D307/94; (IPC1-7): C07D307/79; A01N1/02; A01N43/12; A61K31/34; C07D307/94
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)
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